Drug interactions

Drug interactions between antiretroviral drugs and other medications are complicated. This is a specialist area, often with limited research.

The following sites include drug-interaction resources.

This is the leading global HIV resource that includes an online interaction database and summary print charts.

The Liverpool site produces an individualised report of interactions between any HIV combinations and other drugs, updated to included COVID-19. They also summarise new results presented at major HIV conference and a monthly review of related medical journals.

See also the related site for interactions with hepatitis drugs.

Key UK publication listing all medicines used in the UK, including all formulations and manufacturers of those available as generics. Now hosted by NICE.

A UK commercial lab that still provides therapeutic drug level monitoring (TDM) for complex cases when this test is needed. Also works with the NHS.

Alternative sites

Overview guideline covering main HIV interaction issues that includes a summary table of inducers, inhibitors and substrates of four main P450 enzymes: 1A2, 2C19, 2D6 and 3A4 and another table on the route of elimination for each ARV.

Also includes tables on ARVs and recreational drugsmethadone and buprenorphine.

US-based database that summarises potential drug interactions in both community and professional options.

Online database for information about drugs including interactions. Not HIV-specific and only recognises drugs approved in the US.