Rezolsta (darunavir plus cobicistat)
26 October 2016. Related: ARVs, PIs, PK booster.
This tablet has 800 embossed on one side and TG embossed on the other.
- In November 2014, the EU approved a single pill formulation that contains darunavir (800 mg) plus cobicistat (150 mg).
- Rezolsta is quite large – 23 mm x 11.5 mm. This is larger than most other pills.
- Rezolsta needs to be taken with other HIV meds as part of a combination.
- The adult dose is one pill, once-daily, with food.
- Darunavir is a protease inhibitor that needs to be taken with aonther drug (either ritonavir or cobicistat) to boost drug levels.
- Even with the booster, it is important that darunavir is taken with food.
- Rezolsta therefore needs to be taken WITH food.
- Rezolsta can only be used by people who use once-daily darunavir.
- Rezolsta should not be used if creatinine clearance is less than 70 ml/min if other drugs that need dose adjustment due to creatinine clearance are being used. This includes with FTC, 3TC, tenofovir DF, or adefovir.
- Check with your doctor and pharmacist about drug interactions. Rezolsta can interact with many other drugs. This includes some meds for heart disorders, seizures, allergies, gout, TB, stomach problems, cholesterol (lovastatin and simvastatin), anxiety and erectile dysfunction (including Viagra).
- Please see the web pages for individual drugs for further information on darunavir and cobicistat.
- Link to leaflet about drug interactions between Rezolsta and other medications (PDF)
- Rezolsta is called Prezcobix in the US.
The European patient information and detailed Product Information for atazanavir are available from this link on the European Medicines Agency (EMA) website.
The Patient Information is a simplified summary: what the drug is, why it is used, results from studies and cautions including side effects.
The Product Information is a detailed technical summary that you can access as a PDF file by clicking the ‘Product Information’ tab. It describes more precisely how the drug works and how it is processed by your body. This includes, for example, reported food interaction studies in terms of calories or fat content. It includes more details of the study results and a full list of side effects and drug interactions.