TLD or LTD (tenofovir disoproxil, lamivudine, dolutegravir)

1 August 2024. Related: ARVs, Fixed dose combinations, Integrase inhibitors, NNRTIs.

Picture not included as there are many different versions.

(tee-el-dee)

TLD is a generic HIV combination. It contains tenofovir disoproxil, lamivudine and dolutegravir. Sometime the tablet are marked LTD.

This combination is only available in either low or middle-income countries. Or in some high-income countries where there are a high percentage of HIV positive people. This is because dolutegravir is still under patent in most high-income countries. For example, TLD is not available in Europe, the UK and the US.

There are many generic versions of tenofovir DF, lamivudine (3TC) and dolutegravir coformulated into a single pill (TLD). This is why we have not included a picture because this is manufactured by many different companies.

These include Acriptega, Damicava, Dovimil, Emdolten, Kocitaf,  Kovatrax, Lanograv, Lavern, Luvigen, Milutin, Myteladov, Nuvaco, Odystra, Ranega, Reydin, Telado, Telatri, Temiv, Tladeez, Viripil, Volutrip and Vonavir*.

* Some versions include emtricitabine instead of lamivudine, but they are both very similar.

• TLD is a single pill that should be taken at roughly the same time every day.
• TLD is best taken after you have woken up (rather than before you sleeo). This is because it can stop you sleeping if you take it before you sleep. For most people this will be in the morning or during the day. If you are on shift work and work at night you would take it before you go to work.
• TLD can be taken with or without food.
• It is one of the combinations with the lower risk of side effects. However, a small percentage of people (less than 1 in 20) have trouble sleeping (the reason to take it in the morning) or have mood changes.
• Drug interactions. Not taking at the same time as multivitamin supplements that include calcium, magnesium or aluminium. This also includes antacids that include magnesium or aluminium.
  This requires separating the dolutegravir dose. These products need to be taken a minimum of two hours after dolutegravir or six hours before. Another important interaction is that dolutegravir doubles levels of metformin, and requires careful monitoring.
• Drug interactions. Not taking with some non-steroidal anti-inflammatory drugs (NSAIDs) that are sold over the counter. For example: diclofenac, ibuprofen and naproxen (see tenofovir disoproxil).
• Drug interactions. Please tell your doctor or pharmacist about any other drugs or supplements before taking them with TLD. Drug interactions can also be checked using the online checker at Liverpool University HIV Interaction website:
  https://www.hiv-druginteractions.org/checker
• For more infromation, see: dolutegravir.

There are many generic versions of tenofovir DF, lamivudine (3TC) and dolutegravir coformulated into a single pill (TLD). This is why we have not included a picture because this is manufactured by many different companies.

These include Acriptega, Damicava, Dovimil, Emdolten, Kocitaf,  Kovatrax, Lanograv, Lavern, Luvigen, Milutin, Myteladov, Nuvaco, Odystra, Ranega, Reydin, Telado, Telatri, Temiv, Tladeez, Viripil, Volutrip and Vonavir*.

* Some versions include emtricitabine instead of lamivudine, but they are both very similar.

See this website that includes generics used in South Africa and other countries.

Widely used generic versions of TLD include: