TLD (tenofovir disoproxil, lamivudine, dolutegravir)

24 December 2020. Related: ARVs, Fixed dose combinations, Integrase inhibitors, NNRTIs.

Picture not included as there are many different versions.

(tee-el-dee)

TLD is a generic HIV combination. It contains tenofovir disoproxil, lamivudine and dolutegravir.

This combination is only available in either low or middle-income countries. Or in some high-income countries where there are a high percentage of HIV positive people. This is because dolutegravir is still under patent in most high-income countries. For example, TLD is not available in Europe, the UK and the US.

TLD is a single pill that should be taken every morning at roughly the same time. TLD can be taken with or without food.

It is one of the combinations with the lower risk of side effects. However, a small percentage of people (less than 1 in 20) have trouble sleeping (the reason to take it in the morning) or have mood changes.

The few drug interactions include:

• Not taking at the same time as multivitamin supplements that include calcium, magnesium or aluminium. This also includes antacids that include magnesium or aluminium.
  This requires separating the dolutegravir dose. These products need to be taken a minimum of two hours after dolutegravir or six hours before. Another important interaction is that dolutegravir doubles levels of metformin, and requires careful monitoring.
• Not taking with some non-steroidal anti-inflammatory drugs (NSAIDs) that are sold over the counter. For example: diclofenac, ibuprofen and naproxen (see tenofovir disoproxil).
• For more infromation, see: dolutegravir.

There are many generic versions of tenofovir DF, lamivudine (3TC) and dolutegravir coformulated into a single pill (TLD). This is why we have not included a picture because this is manufactured by many different companies.

These include Acriptega, Dovimil, Emdolten, Lanograv, Lavern, Luvigen, Milutin, Nuvaco, Odystra, Ranega, Reydin, Telado, Telatri, Temiv, Tladeez, Viripil and Volutrip.

See this website that includes generics used in South Africa and other countries.

Widely used generic versions of TLD include: