Daily PrEP: for anal and vaginal sex

Most PrEP studies have used daily PrEP.

Taking PrEP every day will make sure that there are protective drug levels 24 hours a day, 7 days a week. This means you can have sex anytime, without planning for PrEP.

If you generally have sex every week, daily PrEP has the advantage of being an easier routine. Also, missing an occasional dose is unlikely to make a difference.

  • If you are just about to start daily dosing but think you might have a risk within the next few days, start with a double dose.
  • For anal sex, four or more daily doses each week will give good protection, especially after the first week. But four doses a week does not leave room for any missed doses.
  • For vaginal or frontal sex, you need to take PrEP at least six days a week. PrEP needs to be taken for seven days for drug levels to reach full protection.

Last updated: 1 November 2022.