Daily PrEP

Most PrEP studies have used daily PrEP.

Taking PrEP every day makes sure that there are protective drug levels 24 hours a day, 7 days a week, even if you don’t have sex.

This means you can have sex anytime, without planning for PrEP.

• If you generally have sex every week, daily PrEP might be an easier routine.

• Start with a double dose (2 pills) for the first dose. This will protect you within two hours. The pre-dose is important for the highest protection. But if you miss or are late with the pre-dose, start with a double dose as soon as possible. 
• Once on PrEP, continue taking daily PrEP for at least four days each week. It is still okay to take PrEP every day but knowing it is also okay if you miss a few doses should be less stressful. Previously, cisgender women and trans and non-binary people were advised they needed 6/7 doses a week.
• There is currently no data about neovaginal sex. Starting with a double dose and then using daily dosing is therefore a conservative recommendation.

Last updated: 1 February 2025.