Monitoring on PrEP

Once you start PrEP, monitoring is just as important.

If you are currently using oral PrEP and have not been monitored, talk to the clinic about doing this now.

Every 3-4 months

• Have a 4th generation HIV blood test. This is also called an antigen/antibody (Ag/Ab) HIV blood test.
• Have a full screen for other STIs.
• Oral PrEP includes an additional blood test for kidney function (creatinine), which might be needed every six months. This is if you are older than 40 or are at risk of kidney problems. Abnormal kidney results might need monitoring more often.
• Some clinics are now happy for people on oral PrEP to alternate quarterly monitoring between clinic visits and self-sampling postal kits.
• Some clinics might arrange for six-monthly prescriptions for PrEP. 

Every 12 months

• People on oral PrEP need a blood test to check kidney function.
• Test for hepatitis C if you are having sex with gay men. Some clinics do this more frequently depending on risk.

Testing might also be individualised if you are not having sex very often.

For trans and non-binary people

There are no drug interactions between PrEP and hormone treatment. Neither PrEP nor hormone levels are affected. If you are worried about PrEP please speak to your doctor who can also reassure you.

Last updated: 1 November 2025.