Volume 12 Number 3/4 March/April 2011

Welcome to the March/April issue of HTB in which we lead with our first reports from the 18th Conference on Retroviruses and Opportunistic Infections (CROI).

We also include guidelines issued by the London HIV Consortium on prescribing antiretroviral treatment in London clinics for 2011 and basic science reviews by Richard Jefferys.

The London guidelines are likely to be controversial given the decision to prescribe Kivexa-based combinations as preferred first-line treatment for naive patients, when it is clinically appropriate, based on the reduced cost compared to Truvada-based combinations, including Atripla.

This has given cost-based prescribing an elevated profile, though it has been a reality for many years. The higher price for raltegravir is directly related to the limited indications for when it is is used. The London Consortium will include a safety audit from this change of policy which will need to demonstrate that patient safety has not been compromised by the changes.

The clinical guidelines were supported by an advisory panel that included leading doctors from all London hospitals. The changes were less radical than many people expected given the cost pressures facing all NHS departments. In this they minimise changes for people currently on stable treatment.

People currently using Atripla or Truvada-based combinations are not being asked to switch. Athough some people on protease-based combinations will be asked to switch, this should be limited to cases where this has a clinical advantage. People with a complicated treatment history including drug resistance should not be asked to change currently stable protease-based combinations.

Wider public responses to these changes have so far been limited.

The London Consortium had still to post any official documents about the policy change online as we went to press. This will need to include the guidelines and the evidence base that support any changes. Please check the following link for details.


A PDF file was added to this site on Friday 15th April.

The direct URL of this file is:

HTB survey

We’d like to thank everyone who sent back the HTB reader survey distributed with the last edition. The results from the electronic version were impressive but we have less response from the printed surveys.

Please, if you still have this, send them back completed in the SAE or consider doing this online at the following link.

Links to other websites are current at date of posting but not maintained.