May 2002

Contents

Antiretrovirals

• Hydroxyurea: in vitro evidence of potency against HIV viral reservoirs

• Transient increases in viral load are common among people on HAART, finds a study of UK patients

• Meta-analysis supports triple therapy for HIV infection

Pregnancy

• Reduction of mother to child HIV-1 transmission: breastfeeding negates benefits of short course regimens

• Nevirapine at the centre of MTCT controversy

• Mothers, orphans, and prevention of paediatric AIDS

Side effects

• Altered adipocyte differentiation associated with protease inhibitors and lipoatrophy

• High mortality rate in patients with severe NRTI-associated lactic acidosis

• Tenofovir adversely affects development in foetal monkeys

• Tenofovir not toxic to mitochondria in human cell culture

OIs, coinfections and complications

• HIV infection is a risk factor for external genital warts, study suggests

• American study finds KS-associated herpesvirus is highly prevalent among gay men

Other news

• Gilead made misleading and illegal statements about Viread, says FDA

• Barcelona conference organisers issue nine-point plan of action on global emergency

On the web

• Incorporating antiretroviral resistance testing into clinical practice

• Management of co-infection with HIV and TB

PDFs

• Volume 3 Number 4 May 2002 PDF