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2002
November
HTB
November 2002
Contents
Treatment alerts
New safety information for ddI used with ribavirin
US FDA issues new safety information for tenofovir co-administration with ddI
Conference reports
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, 27-30 September 2002
Immunology and treatment interruption data presented at the 42nd ICAAC
Treatment interruptions may result in poor T-cell recovery in patients with nadir CD+ count <50 cells/mm3
Treatment interruptions are safe in patients with CD4+ count between 300 to 500 cells/mm3 and viral loads lower than 70,000 copies/mL
Topical transdermal testosterone gel offers significant clinical benefits in hypogonadal HIV-positive patients
BMS experimental PI atazanavir shows potency comparable to NNRTI efavirenz among treatment-naïve HIV patients
Adverse drug reactions and lipodystrophy in children
Study suggests Kaletra/Combivir is better tolerated PEP than Combivir/nelfinavir
Novel approaches to the inhibition of HIV
Lipodystrophy and adverse drug reaction data presented at the 42nd ICAAC
4th International Workshop on Drug Reactions and Lipodystrophy in HIV Infection, San Diego, 22-25 September 2002
Leptin, lipodystrophy and insulin resistance
A range of treatments for facial lipoatrophy
Autopsy evidence confirms that ARVs tackle CNS lesions
Antiretrovirals
New evidence favours routine measurement of plasma concentrations in salvage therapy to maintain sustained drug levels
European Commission approves new boosted saquinavir regimen (1000 mg saquinavir/100 mg ritonavir twice daily) for the treatment of HIV-1
Treatment access
Profiteers undermine preferential pricing and make millions diverting cheap drugs sent to Africa
Activists win court battle in campaign for generic production of ddI
Global AIDS fund facing bankruptcy
Women's health
HAART enhances regression of cervical intraepithelial neoplasia in HIV-seropositive women
PK and drug interactions
Milk thistle can reduce levels of indinavir in the blood
Side effects
Tamoxifen for male breast enlargement?
Diet can help reduce lipid levels in people with HAART-related dyslipemia
Lipodystrophy syndrome and self-assessment of wellbeing and physical appearance in HIV-positive patients
Coinfections and complications
Intestinal worm eradication lowers viral load in HIV-positive patients
Basic science and immunology
Study shows why some immune systems can control HIV through CD8 cells
PPAR agonists inhibit HIV replication and TNF-alpha production
Many HIV-infected CD4 cells are HIV-specific in patients on HAART
Other news
The Children’s HIV Association of the UK and Ireland – CHIVA
Highlights of the autumn CHIVA meeting
Multivitamins limit HIV transmission through breastfeeding for some women
Prison health services will be taken over by the NHS from next year
Multivitamins limit HIV transmission through breastfeeding for some women
On the web
Diagnosis and management of hepatitis C
HIV-1-associated dementia: a basic science and clinical perspective
Clinicians debate antiretroviral tactics and toxicities, resistance testing, and hepatitis virus coinfection
Lymphoma in the setting of HIV disease
Mitochondrial toxicity in HAART
Mechanisms of T-cell depletion and repletion in HIV disease
HAART interruption strategies: how, when & why?
HIV/AIDS related Spanish language sites, from thirteen different countries.
New treatment information from Visionary Health Concepts
The Guide to Lipodystrophy in HIV
LIPOWatch
Fat in the blood
Current status of ARV treatment interruption and intermittent therapy strategies
Pathogenesis and epidemiology of metabolic abnormalities
Management of morphologic changes during antiretroviral therapy: insights from etiology
Entry inhibitors
Mitochondrial toxicity
HIV medicine after the Barcelona conference: interview with Howard Grossman MD
Once-daily antiretroviral options
PDFs
Volume 3 Number 9 November 2002 PDF
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