HTB homepage • Conference reports • Articles by subject • Subscribe December 2008 Contents Editorial Volume 9 Number 11/12 November/December 2008 i-BASE APPEAL Conference reports 48th Annual International Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 25-28 October 2008, Washington DC Antiretroviral Pregnancy Registry finds no increase in congenital anomalies with exposure to tenofovir No association between maternal antiretrovirals in pregnancy and congenital anomalies Pharmacokinetics of saquinavir/ritonavir in pregnancy Course of labour in pregnant HIV-positive women with no contraindication for vaginal delivery Four weeks of antiretroviral prophylaxis is sufficient for HIV-exposed infants HAART suppresses genital tract HIV shedding in HIV/HSV co-infected women Efavirenz significantly reduces levels of some oral contraceptives Lack of efficacy of isoniazid (INH) prophylaxis and PK evaluation in South African infants 48-week data for darunavir/ritonavir (DRV/r) in treatment-experienced children and adolescents Greater lipodystrophy risk in older US children with low viral load Studies of pipeline drugs: RDEA806, PRO140, bevirimat, elvucitabine Maraviroc trial results reanalysed using more sensitive CCR5 tropism test Other antiretroviral studies at ICAAC High rate of rash in HIV negative volunteers combining raltegravir and darunavir Bone loss in SMART study Parathyroid hormone and vitamin D levels in patients using tenofovir Haemoglobin A1c (HbA1c) may underestimate glycaemia in patients with diabetes on HIV therapy Statin use in HIV-positive patients HIV reinfection reported in 10% of couples in Zambian study Drug interaction studies with approved drugs Non alcoholic fatty liver disease (NAFLD) is common among HIV-positive patients Antiretrovirals FDA approves new paediatric AZT dosing US revisions to darunavir label include once-daily indication for naive patients Baseline renal insufficiency and mortality risk in HIV-positive adults in Zambia Inflammatory and coagulation biomarkers linked to mortality in large treatment interruption trial Treatment access FDA approval of generic ARVs Pregnancy OCTANE Trial DSMB finds ritonavir-boosted lopinavir superior to nevirapine in HIV-positive women previously exposed to single dose nevirapine Antiretroviral therapy in pregnant women and pregnancy outcomes in Abidjan, Cote D’Ivoire Paediatric care Antiretroviral therapy in HIV-positive children in Southern Africa PK and drug interactions Key papers on methadone and ritonavir Guidelines IAS USA resistance guidelines (2008) BHIVA guidelines for immunisation of HIV-infected adults (2008) 2008 European Guidelines (EACS) online US guidelines updated – November 2008 Coinfections and complications Single high dose fluconazole for oropharyngeal candidiasis Basic science and immunology Control of a superinfecting virus in an elite controller Second-oldest HIV-1 sequence identified Why do we not yet have an HIV vaccine? Other news Nobel Prize for medicine awarded to French discoverers of HIV Chinese AIDS activist wins human rights prize On the web Abstracts from the 9th International Congress on Drug Therapy in HIV Infection Abstracts from AIDS Vaccine 2008 Abstracts from BHIVA Autumn Conference, 9-10 October 2008 PDFs Volume 9 Number 11/12 November/December 2008 PDF HTB homepage • Conference reports • Articles by subject • Subscribe
