Q and A


Can I take a zinc supplement with raltegravir?

Is it ok to take zinc supplements with my meds, which are Isentres and Truvada? I take the HIV meds at lunchtime around 12:30, and am thinking of taking the zinc supplements at dinner time around 7:30 pm.


Thanks for getting in touch.

To be on the safe side, due to the raltegravir ( please see here: https://i-base.info/guides/3567) it’s best to take the zinc 6hrs before or after you take your ARVs. Therefore, the times that you’ve mentioned work out fine. However, it’s important to add that this only applies if you’re taking raltegravir twice a day, if you’re on the once a day tablet, you should avoid taking zinc.


  1. Heather

    Thanks Lisa :-)

  2. Heather

    There’s limited information on the potential interaction between zinc and raltegravir, but in general the once daily (yellow 600mg tablets) seem to be affected more by the presence of minerals than the twice daily (pink 400mg tablets). The HIV Pharmacy Association advises avoiding zinc completely if taking once daily raltegravir, and separating zinc and raltegravir by 4-6 hours if the twice daily formulation is used. Links to the HIVPA information leaflets:

  3. Lisa Thorley

    Hi Heather,

    Thanks for these links. I’ve edited the response.


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