Guides

Dovato (dolutegravir + lamivudine)

Dovato is a white tablet embossed with “SV137”. (Source: aidsinfo,nih)

doe-VAR-toe

Dovato is NOT currently licensed in the UK or Europe. It was approved in the US on 08 April 2019.

  • Dovato is a two-drug Fixed Dose Combination (FDC) containing 50 mg dolutegravir plus 300 mg lamivudine (3TC)
  • It is approved in the US for people who are using HIV treatment for the first time and who do not have resistance to either dolutegravir or lamivudine.
  • Dovato can be taken with or without food.
  • Side effects are similar to the individual drugs – see dolutegravir and lamivudine. This is mainly mood changes and sleep disturbance links to dolutegravir.
  • Dovato should not be used by HIV positive people who also need treatment for hepatitis B.
  • There is currently a caution against women using dolutegravir/lamivudine either when conceiving a baby or during the first four weeks of pregnancy. US prescribing information recommends pregnancy testing before starting dolutegravir/lamivudine.
  • There is a drug interaction between dolutegravir/lamivudine and carbamazepine or rifampin. If coadministered with carbamazepine or rifampin, take one tablet of Dovato once daily, followed by an additional dolutegravir 50-mg tablet, approximately 12 hours from the dose of Dovato.
  • Dolutegravir/lamivudine is manufactured by ViiV Healthcare with the brand name Dovato.
  • For full details please see the full prescribing information.

Further information

The US Product Information is also available from this link on the ViiV Healthcare website. Direct link to the PDF format.

The Patient Information is a simplified summary: what the drug is, why it is used, results from studies and cautions including side effects.

The Product Information is a detailed technical summary that you can access as a PDF file by clicking the ‘Product Information’ tab. It describes more precisely how the drug works and how it is processed by your body. This includes, for example, reported food interaction studies in terms of calories or fat content. It includes more details of the study results and a full list of side effects and drug interactions.