First combination
First combination meds
UK guidelines include starting treatment with two nukes plus a third drug.
The 2012 draft recommendations are summarised below.
| Preferred | Alternative | |
| Two ‘nukes’ | tenofovir + FTC (Truvada) | abacavir + 3TC (Kivexa) |
| Plus a third drug | efavirenz (NNRTI) or
atazanavir/r (boosted PI) or darunavir/r (boosted PI) or raltegravir (integrase inhibitor) |
lopinavir/r (boosted PI) or
fosamprenavir/r (boosted PI) or nevirapine (NNRTI) or rilpivirine (NNRT |