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Guides Introduction to combination therapy

First combination

First combination meds

UK guidelines include starting treatment with two nukes plus a third drug.

The 2012 draft recommendations are summarised below.

Preferred Alternative
Two ‘nukes’ tenofovir + FTC (Truvada) abacavir + 3TC (Kivexa)
Plus a third drug efavirenz (NNRTI) or

atazanavir/r (boosted PI)  or

darunavir/r (boosted PI)  or

raltegravir (integrase inhibitor)

lopinavir/r (boosted PI)  or

fosamprenavir/r (boosted PI)  or

nevirapine (NNRTI) or

rilpivirine (NNRT



April 2012

Decisions relating to your treatment should always be taken in consultation with your doctor. Information in this guide is intended to support those discussions.

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