1 February 2008

Contents

Conference reports

• 15th Conference on Retroviruses and Opportunistic Infections, 2-6 February 2008, Boston

• Increased risk of myocardial infarction associated with abacavir and ddI

• Position statement by the D:A:D steering committee

• 3rd International Workshop on Targeting HIV Entry, 7-9 December 2007, Washington DC

• CXCR4-using HIV found in 8.5% during early HIV infection

• Background drugs and low maraviroc levels explain resistance in Motivate studies

• 38th World Conference on Lung Health of the Union Against TB and Lung Disease, December 2007, Cape Town

• Treatment outcomes in patients who received rifampicin with nevirapine or efavirenz

Antiretrovirals

• Boehringer fails to register tipranavir in Brazil after using Brazilian patients in registrational study

• Raltegravir approved in Europe and available in the UK

• Paediatric lopinavir/r receives positive opinion from EMEA

• Etravirine (TMC-125) approved in the US

• Changes to atazanavir product label in US

• HIV-positive adults with CD4 >500 cells/mm3 have similar mortality rates as the general population after seven years ARV treatment

Pregnancy

• Atazanavir exposure in pregnancy

• Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-positive pregnant women

Paediatric care

• Predictors of mortality in untreated HIV-positive children

• Pharmacokinetics of lopinavir/ritonavir in infants less than 12 months of age

PK and drug interactions

• Darunavir/ritonavir interaction with clarithromycin warrants caution

• Updated and new resources on HIV drug interactions

Guidelines

• US treatment guidelines updated (2008)

Hepatitis coinfection

• Comparative study of pegylated interferon formulations in HCV monotherapy

Basic science and immunology

• Probing HIV dependence on host proteins

• An eye on the benign: pathogenesis lessons from non-pathogenic SIV infections

• HIV awakens retroviral zombies from cellular slumber

• Immune activation correlates with CD4 T cell declines in HIV controllers

Drug resistance

• Dual-class mutations affection RTI and NNRTI may be common in experienced patients

On the web

• 58th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)

• Targeting HIV Entry: 3rd International Workshop

• PLoS Medicine

• Breakthroughs in immunology

• Multiple roles of CCR5 in infectious diseases

• New resources from HIV inSite

• New advocacy site: HIV and pregnancy

PDFs

• Volume 9 Number 1/2 January/February 2008 PDF

• CROI 2008: 12 key areas of research – non-technical summary of 25 studies and presentations