Multiple roles of CCR5 in infectious diseases

1 February 2008. Related: On the web.

Three free access papers from the online first section of the Journal of Infectious Diseases. The articles highlight the role of CCR5 – better known as a co-receptor for HIV entry into cells – in T cell trafficking to sites of infection and suggest that studies are needed to evaluate the effects of pharmacological inhibition of CCR5 in these settings.

A moving target: the multiple roles of CCR5 in infectious diseases

Robyn S. Klein

http://www.journals.uchicago.edu/doi/full/10.1086/524692

Genetic deficiency of chemokine receptor CCR5 Is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of four cohorts in the US epidemic

Jean K. Lim et al.

http://www.journals.uchicago.edu/doi/full/10.1086/524691

A deletion in the CCR5 gene is associated with tickborne encephalitis

Elin Kindberg et al.

http://www.journals.uchicago.edu/doi/full/10.1086/524709

The Journal of Infectious Diseases http://www.journals.uchicago.edu/toc/jid/0/0