Q and A

Question

What is a normal CD4 count, CD4% and CD4:CD8 ratio?

Answer

CD4 cells are a type of blood cell that is part of your immune system. They are a type of white blood cell (lymphocyte). CD4 cells are sometimes called T-helper cells or T-cells

There are two main types of T-cells.

  1. CD4 cells, also called T4 cells, are “helper” cells. They lead the attack against infections.
  2. CD8 cells, (T8 cells), are “suppressor” cells that complete the immune response. CD8+ cells can also be “killer” cells that kill cancer cells and other cells that are infected by a virus.

CD4 and CD8 counts

The normal ranges for CD4 and CD8 counts vary depending on the lab and test. On average, the normal CD4 range for an HIV negative person is between 460 and 1600. This is an average. Anywhere in this range is fine.

Although generally a higher CD4 is good, an HIV negative person with a normal CD4 count of 1200 is not more healthy than someone whose normal count is 400.

A normal CD8 range is from 150 to 1000. This test is not really used so much for monitoring HIV. It is more important to know your CD4 count than your CD8 count.

The exact CD4 count is not so important. CD4 counts can vary from day to day and even from hour to hour. So the general CD4 result is more important than the exact number.

If you get a CD4 count that is ever unexpectedly high or low, then your CD4% (CD4 percentage) will indicate if this is a real change. This percentage is more stable than the exact CD4 count.

CD4 percentage (CD4%)

The CD4 percentage refers to percentage of total lymphocytes that are CD4 cells. If your test reports CD4% = 34%, that means that 34% of your lymphocytes are CD4 cells.

The average normal CD4% for HIV negative adults is about 40%. However, as with CD4 counts and other test, the range for a “normal” result in an HIV negative person is also wide – from about 25% to 65%.

CD4:CD8 ratio

The CD4:CD8 ratio is also sometimes used, but less often. This is a measure of how balanced your immune function is. This calculated by dividing the CD4 result by the CD8 result.

In HIV negative people, the normal range for the CD4:CD8 ratio is between 0.9 and 1.9. This means that there are about 1 to 2 CD4 cells for every CD8 cell.

When not on HIV treatment, just like the CD4 count and CD4%, the CD4:8 ratio drops over time. Eventually, unless you start treatment, there will be more CD8 cells than CD4 cells (i.e. the ratio drops to less than 1.0).

Recent studies have suggested that the CD4:8 ratio might be more accurate than the CD4 count at predicting future risk in people whose CD4 count is high (above 350 cells/mm3).

Other studies have shown that starting ART soon after HIV infection has a much higher chance of keeping the CD4:CD8 ratio higher than 1.0.

Note: this answer was updated in September 2014 and December 2016 from a post that was originally published in December 2006.


Information on this website is provided by treatment advocates and offered as a guide only. Decisions about your treatment should always be taken in consultation with your doctor.

95 comments

  1. Aristo

    What can I eat to boost my CD4?

  2. Lisa Thorley

    Hi Aristo,

    What’s your CD4 count? How long have you been on meds?

    Side effects from taking septrin aren’t that common. Please see here:

    http://i-base.info/qa/11437

    Therefore, this is something that you will need to talk to your doctor about.

  3. Aristo

    hello am HIV + from Nigeria.
    I was diagonise in 2012. I was put on drugs(septrin) because my my CD4 was high. I the stopped taking it. In 2016 I fell ill, severally. I went back to same hospital and I was given septrin. I reacted to it causing my body to change. I went back and told the doctor. Later he told me that septrin wasn’t good for me. My question is why did I react badly? I’m on ARVs.

  4. Lisa Thorley

    Hi Dan,

    Unfortunately your weight cannot be used to indicated if your CD4 is rising or not. However, if you’re on meds, which you are, then it should be rising. To know this for sure though, your CD4 will need to be tested. As too will your viral load if that is possible.

    You say that your weight was 73kg when you first started meds. Has it always been like this, or did you weigh more? I ask this as weight gain can be an indicator that your body is becoming healthier. This may only apply though if you have lost a lot of weight.

    The weight gain may also be a side effect of the meds that you are taking. What is it that you’re taking? Is there any possibility that you can have your CD4 redone?

    With regards to your CD4, when you started it was low. Where you given any other medication to take? How has your health been?

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