Benefit of staying on treatment using drugs that are still active

Even if you have a detectable viral load and are waiting for new treatments, staying on treatment with nukes and a protease inhibitor is safer than stopping all your drugs.

Even with drug resistance, it is better to continue to use some meds compared to stopping treatment altogether.

This is especially important if your CD4 count is less than 200.

As long as you are able to tolerate treatment, nukes and PIs are likely to still help.

If you have the key mutations associated with resistance to NNRTIs, T-20 or integrase inhibitors, then there may be no nbenefit from still taking them as they are unlikely to still be active.

If the next new drug you are waiting to use is a PI, cutting back to a nuke-only ‘holding’ regimen will reduce the risk of developing further cross-resistance to the new PI.

If the next drug you are waiting for is a nuke, it may be better to use boosted-PIs in the holding regimen.

This short-term approach needs more frequent monitoring.

Last updated: 1 January 2018.