Changing ART: what to do if viral load rebounds
This is a resource about changing HIV treatment (ART) and drug resistance. (August 2021).
This covers about 50 pages online (many of them are short). The PDF booklet is an 8-page summary with links to the online sections.
- Reasons to change ART
- If your viral load never became undetectable…
- What if your viral load rebounds?
- Viral load blips
- Confirmed viral rebound
- How can drugs “fail” when I feel fine?
- Do some drugs develop resistance more easily?
- Why adherence is linked to drug resistance
- What if I forget my meds?
- Adherence tips
- Adherence diary
- Important monitoring tests
- Viral load tests
- Resistance tests
- What resistance test results mean
- TDM (Therapeutic Drug Monitoring)
- IQ and VIQ
- Viral tropism
- Getting the tests in the UK
- When should I change and which drugs can I use?
- How do I choose new drugs?
- General principles
- Cross-resistance by drug class
- When to use new drugs and when to wait?
- Pipeline drugs
- Expanded access drugs
- Non-ARV drugs
- Other treatment strategies
- Intensify treatment
- Using T-20
- Using five or more drugs
- Treatment interruptions
- Drug recycling using viral fitness
- Benefit of staying on treatment using drugs that are still active
This guide was written and compiled by Simon Collins for HIV i-Base. Thanks to the advisory group of HIV positive people and healthcare professionals for comments and to MAC AIDS FUND for funding this publication.
Information about how we produced this guide and the importance of using language that is direct and easy to understand.
This includes information on how to write non technical medical information that may be useful as a resource for other organisations.
Last updated: 1 August 2021.