Does PrEP interact with other medications?

PrEP does not interact with most other medicines.

But if you routinely take other prescribed meds, tell your doctor (including your GP) that you are taking PrEP.

You can also ask a pharmacist to check for drug interactions. This includes with over-the-counter meds.

Tenofovir (TD) should be used with caution with some other drugs that can affect the kidneys.

These include some non-steroidal anti-inflammatory drugs (NSAIDs), especially diclofenac, ibuprofen and naproxen. Short-term use for a few days will be okay, but routinely taking both drugs together can cause kidney problems.

Avoid these meds with PrEP, or let your doctor know if you regularly need to take them.

Although used more rarely, TAF can interact with TB meds, anti-epileptics, St John’s Wort and others. This isn’t a problem with TD.

For trans and non-binary people

PrEP is very safe for trans and non binary people taking hormone therapy.

Info on interactions between PrEP and other meds, including hormone treatment is on this site from Liverpool University:

Last updated: 1 November 2022.