Additional benefits of exercise with metformin
1 September 2003. Related: Conference reports, Lipodystrophy and metabolic complications, Lipodystrophy Workshop (IWADRW) 5th Paris 2003.
Simon Collins, HIV i-Base
Driscoll and colleagues reported that exercise training (one hour of aerobic plus strength training three times a week) together with metformin (850mg BID) significantly improved cardiovascular risk markers (waist-to-hip ratio, resting systolic and diastolic blood pressures and aerobic capacity to exercise) compared to metformin alone. [19]
The study population included 37 HIV-positive patients on HAART with hyperinsulinaemia or impaired glucose tolerance and waist-to-hip ratio >0.90 in men or >0.85 in women. Only 25 people completed the study, which unfortunately did not include an exercise-only arm. Diet did not change during the study.
This article is part of a longer report from the 5th International Workshop on Adverse Drug Reactions and Lipodystrophy, 8-11 July 2003, Paris. Part seven of this report.
Reference:
Unless otherwise stated, all abstracts refer to the programme and abstracts from the 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 8-11 July 2003, Paris and are published in Antiviral Therapy Volume 8 issue 4.
- Driscoll S, Meininger G, Lareau M et al – Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients. Abstract 4.