Additional benefits of exercise with metformin

Simon Collins, HIV i-Base

Driscoll and colleagues reported that exercise training (one hour of aerobic plus strength training three times a week) together with metformin (850mg BID) significantly improved cardiovascular risk markers (waist-to-hip ratio, resting systolic and diastolic blood pressures and aerobic capacity to exercise) compared to metformin alone. [19]

The study population included 37 HIV-positive patients on HAART with hyperinsulinaemia or impaired glucose tolerance and waist-to-hip ratio >0.90 in men or >0.85 in women. Only 25 people completed the study, which unfortunately did not include an exercise-only arm. Diet did not change during the study.

This article is part of a longer report from the 5th International Workshop on Adverse Drug Reactions and Lipodystrophy, 8-11 July 2003, Paris. Part seven of this report.


Unless otherwise stated, all abstracts refer to the programme and abstracts from the 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 8-11 July 2003, Paris and are published in Antiviral Therapy Volume 8 issue 4.

  1. Driscoll S, Meininger G, Lareau M et al – Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients. Abstract 4.

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