PLoS Medicine (July 2012)

This month, PLoS Medicine includes a broad range of HIV related papers.

The ethics of switch/simplify in antiretroviral trials: non-inferior or just inferior?

Andrew Carr, Jennifer Hoy, Anton Pozniak

Paper discussing the limitations and ethics for antiretroviral switch studies using the MONET and SWITCHMRK studies are examples.

Treatment of young children with HIV infection: using evidence to inform policymakers

Andrew Prendergast, Di Gibb et al.

Paper evaluating the evidence for a change in policy for the treatment of young HIV positive children and infants, including when to start wand optimal choice of combination.

HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa

Jeffrey Eaton et al.

Article discussing modelling approaches to the use of ARV treatment as prevention.

Accompanied by ten discussion papers.

Antiretroviral therapy for prevention of tuberculosis in adults with HIV: a systematic review and meta-analysis

Amitabh Suthar, Stephen Lawn, Reuben Granich et al.

In a systematic review and meta-analysis, Amitabh Suthar and colleagues investigate the association between antiretroviral therapy and the reduction in the incidence of tuberculosis in adults with HIV infection.

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