Conference on Retroviruses and Opportunistic Infections (CROI 2019): early reports
Simon Collins, HIV i-Base
This year the Conference on Retroviruses and Opportunistic Infections (CROI 2019) was held from 4–7 March in Seattle.
The meeting had an exciting programme with research that will be reported over at least the next three issues of HTB.
Headline news included:
- Breakthroughs in cure research including two new cases of potential cures – defined as sustained remission off-ART. One case is from the UK and another from Germany. Limited case details were reported in a New York times article before the CROI presentations.
- HIV and pregnancy including studies looking at risk of neural tube defects at conception with integrase inhibitors.
- Pipeline HIV drugs, including bNAbs and long-acting formulations and new classes of capsid inhibitors and maturation inhibitors.
- PrEP (including first results with TAF).
- Numerous complications, including obesity, cardiovascular risk and bone health.
- Side effects, including whether integrase inhibitors are linked to weight gain.
CROI is notable for providing same-day or next-day webcasts for most talks and comprehensive online access to abstracts and PDF files for posters.
This year HTB with include summary highlights for each day of the conference, with links to key studies.
Early articles will be posted as links below.
- Double doses of darunavir given with rifampicin lead to high rates of hepatoxicity
- New option for PrEP – TAF/FTC is non-inferior to TDF/FTC: results of phase 3 DISCOVER study
- Viral reservoir can explain persistent low level viraemia with good adherence on ART
- Phase 3 results with dual therapy cabotegravir/rilpivirine long-acting injections: ATLAS and FLAIR studies
- Shared housing compared to living alone: higher CD4, lower viral load and reduced inflammation in macaques
- Dolutegravir suppresses viral suppression faster than efavirenz in late pregnancy: results from DolPHIN-2
- UK patient likely to be the second person cured of HIV: two further cases at CROI 2019 of HIV remission after allogenic stem cell transplants
- i-Base Fit for Purpose report launched at CROI 2019
- Pre-CROI Community HIV Cure Workshop 2019