HTB

Immunorestitution disease

Polly Clayden, HIV i-Base

Immunorestitution disease (IRD) is the paradoxical clinical deterioration of a pre-existing condition that can sometimes accompany the recovery of the immune system.

A report in the June issue of Clinical Infectious Diseases reviews the sequence of events as occurred previously published reports of IRD in HIV-infected patients after the initiation of HAART. The investigators found that for IRD due to mycobacteriosis (n=27) and cryptococcosis (n=4) the mean interval between the initiation of HAART and the onset of IRD was 11 days; and for viral infections due to cytomegalovirus (n=14), hepatitis B (n=1) and hepatitis C (n=2) the median interval was 42 days.

They concluded that ‘As an emerging clinical entity, IRD merits further study to optimise treatment of immunosupressed patients.’

Reference:

Immunorestitution disease involving the innate and adaptive response. Cheng et al. Clin Infect Dis 2000 June; 30(6):882-92

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