US perinatal treatment guidelines updated

January 24, 2001

The HIV/AIDS Treatment Information Services (ATIS) announces the release of the updated Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1 Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States guidelines.

The primary changes include:

  • An expanded section on mitochondrial toxicity and nucleoside analogue drugs and issues in pregnancy. Recent data released by Bristol-Myers Squibb reported 3 maternal deaths due to lactic acidosis, 2 with and 1 without accompanying pancreatitis, in women who were either pregnant or postpartum and whose antepartum therapy during pregnancy included d4T/3TC at the time of conception and throughout pregnancy who presented with symptoms and foetal demise at 38 weeks gestation.
  • A new section on Preconceptional Counseling and Care for HIV-Infected Women of Childbearing Age has been added.
  • An updated discussion section of the Antiretroviral Scenarios #1 and #2 and #4.

The updated guidelines are available at:

Links to other websites are current at date of posting but not maintained.