US perinatal treatment guidelines updated
January 24, 2001
The HIV/AIDS Treatment Information Services (ATIS) announces the release of the updated Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1 Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States guidelines.
The primary changes include:
- An expanded section on mitochondrial toxicity and nucleoside analogue drugs and issues in pregnancy. Recent data released by Bristol-Myers Squibb reported 3 maternal deaths due to lactic acidosis, 2 with and 1 without accompanying pancreatitis, in women who were either pregnant or postpartum and whose antepartum therapy during pregnancy included d4T/3TC at the time of conception and throughout pregnancy who presented with symptoms and foetal demise at 38 weeks gestation.
- A new section on Preconceptional Counseling and Care for HIV-Infected Women of Childbearing Age has been added.
- An updated discussion section of the Antiretroviral Scenarios #1 and #2 and #4.
The updated guidelines are available at: