Prevalence of the T215Y mutation in HIV type 1-infected pregnant women in a New York cohort, 1995-1999

30 July 2001. Related: Pregnancy, Drug resistance.

From 1997 through 1999, the prevalence of the zidovudine resistance mutation T215Y was 9.7% among pregnant women, and the human immunodeficiency virus type 1 (HIV-1) load in those with resistant virus was higher than that measured in women with wild-type HIV-1.

All mutations were noted in women with zidovudine experience, which suggests that monotherapy may not be adequate prophylaxis for vertical transmission of HIV-1 infection in the current era.

Reference:

Sitnitskaya Y, Rochford G, Rigaud M et al. Clin Infect Dis 2001 Jul 1;33(1):E3-7.