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2001
July
HTB
July 2001
Contents
Conference reports
5th International Workshop on HIV Drug Resistance, 4-8 June 2001, Scottsdale, Arizona
Anti-HIV immune responses and partial viral suppression
HIV resistance, phenotypic drug susceptibility and viral fitness
SWATCH – alternating antiretroviral regimens
Structured treatments interruptions
Importance of additional active drugs for NNRTI-naive patients using NNRTI-based salvage regimens
NNRTI and PI drug plasma levels are as critical as drug sensitivity in achieving treatment success in antiretroviral experienced patients
Increased prevalence of transmission of drug resistant HIV and reduced response in newly infected subjects in nine US cities
Role of codon-69 variants in reduced susceptibility to nucleoside analogues
Selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug naive people
Nucleoside resistance pathways may differ between HIV-1 and HIV-2
Role of Y318F mutation in NNRTI resistance
Antiretrovirals
T-20: will long-term use weaken the immune system’s ability to fight HIV?
The steady-state pharmacokinetics of efavirenz and nevirapine when used in combination in human immunodeficiency virus type 1-infected persons
Ritonavir approved in Europe as pharmacokinetic enhancer for use with other antiretrovirals
Treatment access
Abbott Labs cuts prices on many drugs, treatments amid pricing investigation
Yale economist introduces proposal to settle debate between pharmaceutical companies and developing nations
Kenyan lawmakers approve bill to suspend drug patent rights and improve cheaper drug access
South African government issues first draft of legislation allowing importation of discounted pharmaceuticals
International aid group to begin administering AIDS drugs to small group of poor South Africans
Britain to Donate £75 million to global AIDS fund
Uganda to offer free HIV drugs to pregnant women to prevent vertical HIV transmission
Women's health
HIV-positive women at high risk for pre-cancerous anal lesions
Pregnancy
Breastfeeding may increase maternal mortality among HIV-positive women, study shows
Prevalence of the T215Y mutation in HIV type 1-infected pregnant women in a New York cohort, 1995-1999
PK and drug interactions
A warning about milk thistle (silymarin) and drug interactions
Side effects
Sexual dysfunction associated with protease inhibitor containing HAART
Nevirapine use linked to icteric hepatitis in some HIV-positive patients
Tattoos flare up from HAART
Treatment of hyperlipidemia in HIV-positive patients
Cure-related research
Thai officials call for cancellation of AIDS ‘miracle cure’ distribution amid controversy
Basic science and immunology
Immunologic profile of HIV-positive patients during viral remission and relapse on antiretroviral therapy
Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
Basis of HIV resistance suggests new vaccine strategy
Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
Other news
African advocacy groups call for dismissal of USAID director Natsios after ‘racist comments’
Canada Reverses ban on entry of HIV-positive immigrants
Bristol-Myers Squibb agrees to purchase DuPont’s drug business
NEJM commemorates 20 years of AIDS with early-release retrospective
New York’s Beth Israel Hospital making post-exposure HIV treatment available to general public
On the web
Strategies to cut risky sexual behaviour may do more harm than good
ABC of AIDS – HIV infection and AIDS in the developing world
Current review on hepatitis C virus in HIV/HCV coinfection
ABC of AIDS – antiretroviral drugs
PDFs
Volume 2 Number 6 July 2001 PDF
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