Insights into HIV-specific CD4+ T cell immunity

Ronald B Moss

Greater understanding of the role of HIV-specific immunity remains fundamental to current and future therapies to prevent and treat HIV infection. The induction of HIV-specific immunity in seronegative individuals might involve similar or different effector cells of the immune system compared to individuals who are infected and maintain a reservoir of latently infected cells on or off antiviral drugs. This short review will focus on recent understanding of HIV-specific immunity in HIV-infected individuals. Specifically, the role of the CD4+ T helper cell in HIV-specific immunity will be addressed.

Source: AIDScience Vol. 2, No. 12, June 2002

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