6th International Workshop on Clinical Pharmacology of HIV Therapy, 28-30 April 2005, Quebec, Canada

Reports from the conference

An understanding that the complexity of pharmacological issues relating to HIV treatment is rooted in individual treatment responses, helps explain the limitations of a ‘one-size-fits-all’ approach to treatment. This annual meeting always produces important studies and this year was no exception, with many more interesting studies than we are able to cover in detail in this issue of HTB.

Important reports below include the role of age, weight and gender in drug metabolism. Additionally, new data on important drug interactions were presented, sometimes with drugs that have been approved and used together for several years in the absence of formal data.

Abstracts from the meeting are available to download from the conference website. Each section has to be downloaded as a separate pdf file, from a link at the bottom of the list of abstracts in that section – select appropriate meeting, then abstracts, then section, then click a half-hidden link at the bottom of the page – somewhat obscure, but worth it…

An excellent range of additional reports by Mark Mascolini, one of which is included in this issue, are also available from:


  • Effect of age/menopause on lopinavir and efavirenz concentrations in women
  • Effect of age on lopinavir concentrations
  • Gender and pharmacokinetics of saquinavir
  • Dosing nevirapine in children
  • Intracellular NRTI-triphosphate levels in children are similar to adults
  • Efavirenz and rifampicin during pregnancy: lower body weight associated with higher concentrations
  • Summary of drug interaction studies
  • Responses to atazanavir, Kaletra and side effects

Links to other websites are current at date of posting but not maintained.