Updated UK guidelines for HIV and hepatitis coinfection (2005)
29 January 2005. Related: Guidelines, Hepatitis coinfection.
Updated guidelines are now available on the British HIV Association BHIVA website.
The major changes for each section include:
HBV coinfection
- Reformatted in the style of the ART guidelines.
- Treatment algorithms added.
- New, clearer definitions of when to treat and with what.
- High CD4: ideally treat according to liver biopsy result. Options are to use interferon if HBeAg +ve (non-cirrhotic) and abnormal LFT or adefovir in those who are HBeAg +ve or HBeAg –ve and HBV-DNA >104 copies/ml (>103 if cirrhosis)
- Low CD4 requiring ART: treat according to HBeAg status and HBV-DNA (as above). Can use tenofovir alone as part of HAART. 3TC/FTC are only recommended in combination with tenofovir.
- Updated clinical trial evidence and references.
- New information on investigations and vaccination.
HCV coinfection
- Reformatted in the style of the ART guidelines.
- Recommended treatment is with pegylated interferon and ribavirin
- Non-pegylated interferon is no longer recommended
- Updated information on clinical trails and references
- Deletion of discussion on non-pegylated interfero
- Recommend avoid AZT and ddI in those on ribavirin.