44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 30 October-2 November 2004, Washington

31 January 2005. Related: Conference reports, Conference index, ICAAC 44th Washington 2004.

Simon Collins, HIV i-Base

Report from the conference.

• Tipranavir in treatment experienced patients: results from RESIST-1

• Reverset: first data in patients with nucleoside resistance

• Poor response with tenofovir and ddI backbone causes early study termination

• Paradoxical CD4 response with tenofovir and ddI backbone

• Tenofovir/FTC backbone outperforms AZT/3TC (Combivir) with efavirenz in treatment naive patients; reduced toxicity drives ITT viral efficacy

• Limited stability of lopinavir/r (Kaletra) above 25°C

• Atorvastatin requires dose reduction with tipranavir/r

• Once-daily T-20 is less effective than twice daily: lower potency is related to C trough

• Further genetic link to efavirenz absorption

• Long-term response to FTC in children is similar to adults

• Side effects update: hypersensitivity, heart, bones

Over the last few years the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) has had a reduced focus on HIV. This years meeting however included several important oral presentations and posters of interest.

ICAAC still maintains a restricted approach to making the research presented at these annual meetings available publicly. Although the website currently includes searchable abstracts, webcasts of many oral sessions, and the slides from some of these presentations, this is only for one month after the conference. The meeting is then available on CD Rom for around $300, but the public access stops. Notably, this conference still refuses to allow these abstract to join the online resource developed by AEGiS.org.

Unfortunately, abstracts that are currently available on the conference website are linked to pop-up windows, and this means that we are not able to provide direct weblinks for referenced articles in the way HTB does for routine conference coverage.

Abstracts can nevertheless be browsed and searched from this web address:

www.abstractsonline.com/viewer/browseOptions.asp?MKey={CE64B3B3-6CEB-40D2-ACDF-
14A2BE602044}&AKey={32093528-52DC-4EBE-9D80-29DAD84C92CE}

Conference coverage also provided by the following sites:

• www.thebody.com/confs/icaac2004/complete.shtml
• www.natap.org

Abstract summaries organised by subject are provided by:

• www.hivandhepatitis.com/2004icr/icaac2004/main.html
• clinicaloptions.com/hiv/conf/icaac2004

Unless otherwise stated, all references are to the Abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 30 October – 2 November 2004, Washington, DC.