Liverpool University launches new PrEP drug interaction website: covers oral, injectable and ring-based PrEP
6 May 2026. Related: Early access, PK and drug interactions, BHIVA/BASHH 6th Liverpool 2026.
Simon Collins, HIV i-Base
An essential new PrEP resource was launched at the 6th BHIVA/BASHH conference by the same team that run the main drug interaction website at Liverpool University.
https://prep-druginteractions.org/.
The new site is based on two main PrEP resources.
- A new interaction checker with a pull-down menu that only lists PrEP drugs (rather than all ARVs) checked against a database of over 1100 compounds.
https://prep-druginteractions.org/checker - An information section that includes ‘at-a-glance’ factsheets for each PrEP formulation, using a red/amber/green traffic-light system for contraindications, caution or all-clear results.
https://prep-druginteractions.org/prescribing_resources
Information about drug interactions with oral PrEP is based on daily dosing.
The website is notable for reporting many interactions that might not be included in the summary of product characteristics and product information of each PrEP option. Some of the contraindications might not be expected or otherwise reported and they will be especially important for new versions of injectable PrEP.
For example, there are 18 contraindications with cabotegravir injections listed below (with an additional eight marked as orange cautions). CAB-LA should not be used with African potato, apalutamide, carbamazepine, dabrefanib, enzalutamide, esticarbazepine, fosphenytoin, griseofulvin, hexobarbital, ivosidinib, malabar nut tree, oxcarbazepine, phenobarbital, phenytoin, rifampicin, rifapentine and St John’s Wort.
The summary for lenacapavir PrEP is more complicated for including 57 contraindications (marked red – and too many to lis here) and more than 170 compounds where there is a potential caution (marked orange).
Hyperlinks to each of the PDF summaries are below.
- Cabotegravir PrEP injections
- Cabotegravir PrEP tablets
- Dapivirine vaginal ring
- F/TAF – emtricitabine + tenofovir alafenamide (Descovy and generics)
- F/TDF – emtricitabine + tenofovir-DF (Truvada and generics)
- Lenacapavir PrEP injections
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This new website instantly becomes an essential global resource that needs to be known by all prescribing doctors and hopefully everyone using PrEP.
It reports on likely interactions for all current PrEP formulations against a database of more than 1100 medicines, supplements, foods, recreational drugs (including for chemsex) and other compounds.
The team also welcomes feedback and plans to continue developing these resources for PrEP users and health professionals.