June 2002

Contents

Conference reports

• 9th Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, Februrary 24-28 2002

• New research points the way for future treatment of women with HIV

• 3rd International Workshop on Clinical Pharmacology of HIV Therapy, Washington, 11-13 April 2002

• Three studies compare gender differences in use of antiretrovirals

Antiretrovirals

• Amprenavir mutations may significantly affect LPV resistance

• 24-week results from phase III study of HIV fusion inhibitor T-20

• Abacavir treatment limited by prior NRTI exposure

Treatment access

• WHO releases guidelines for use of antiretroviral drugs to treat HIV infection in developing countries (2002)

• Mbeki backs down: he shuns dissidents and expands drug treatment programme

• Early access programme offers adefovir for treatment of HBV

Paediatric care

• CCR5 density on CD4 cells governs course of HIV infection in children

• Saquinavir is a suboptimal treatment for children unless used in combination

Guidelines

• First audit of BHIVA treatment guidelines reveals suboptimal access to viral load and resistance tests

Side effects

• Neuropsychiatric complications of nevirapine treatment

• Paracardial fat in HIV-infected patient resembles pericardial effusion

Coinfections and complications

• Filgrastim seems to increase survival in AIDS patients but the mechanism remains unclear

• Oral valganciclovir is as effective as intravenous ganciclovir for induction treatment of CMV retinitis

Basic science and immunology

• Measles found to suppress HIV

Drug resistance

• Resistance mutations continue to accumulate with low-level viral increases

• Resistance to template-analogue inhibitors linked to impaired replication

Other news

• New cancer drugs might help treat HIV — but research not done

• First report of acquired HCV immunity lifts vaccine hopes

• Manganese blocks HIV replication; lab finding points to a potential new class of HIV treatments

• Turmeric may slow multiple sclerosis progression

• 1,500 community representatives expected at Barcelona community forum

On the web

• Fibrates and statins and glitazones (oh my!)

• Nutrition and immunity: you are what you eat

• The role of dietary supplements in HIV

• Using evidence to make nutrition decisions: a look at zinc

• Peripheral neuropathy

• A potent weapon in the battle against HIV: your own immune system

PDFs

• Volume 3 Number 5 June 2002 PDF