April 2008

Contents

Editorial

• Volume 9 Number 3/4 March/April 2008

• i-Base funding withdrawn: urgent request for letters of support

Conference reports

• 15th Conference on Retroviruses and Opportunistic Infections, 2-6 February 2008, Boston

• Atazanavir/r vs lopinavir/r in treatment-naive patients: 48 week results

• Baseline inflammation and coagulation markers and changes over four weeks during a treatment interruption are strongly linked to HIV viraemia and risk of mortality

• Restarting treatment after an interruption reduces the risk of serious events but CD4 recovery falls short of baseline levels

• Very low rate of MTCT in women on HAART in UK and Ireland who achieve viral suppression

• Predictors of mother to child transmission among women initiating HAART in pregnancy in a South African cohort

• Maternal and infant outcomes from the DREAM programme

• Nevirapine-resistant HIV present in the latent reservoir following single-dose nevirapine for MTCT prevention

• Tenofovir plus FTC reduce NNRTI resistance following single dose nevirapine

• Response to treatment after single dose NVP exposure in women

• Response to treatment after single dose NVP exposure in infants

• Other studies looking at birth outcomes

• Infant prophylaxis for postnatal transmission

• Antiretroviral drug concentrations in breast milk and breastfeeding infants

• Maternal breastfeeding prophylaxis

• Risk factors for breastfeeding transmission

• UK cohort reports sexual HCV reinfection in at least 5% HIV-positive gay men following sustained response to treatment

• MELD score predictive of pre-transplant mortality in HCV coinfected patients

• Does abacavir decrease SVR rates with HCV treatment?

• No effect of interferon maintenance therapy on fibrosis progression in non-responders

• Stem cell transplant from HLA-matched CCR5-delta 32 deleted donor suppresses viraemia in recipient for 8 months without HAART

• Risk factors for AIDS-defining and non AIDS-defining cancers

Antiretrovirals

• FDA approve 600mg darunavir tablet

• US study changes use of abacavir/3TC in naive patients with viral load >100,000 copies based on DSMB recommendation

Treatment access

• New PMTCT guidelines for South Africa (Feb 2008)

Basic science and immunology

• A gutsy talk, and a new paper: report from third workshop on HIV persistence

Other news

• Managing stigma – report into gay and bisexual African men with HIV released

PDFs

• Volume 9 Number 3/4 March/April 2008 PDF