22 August 2009

Contents

Conference reports

• XVIII International Drug Resistance Workshop, 9-13 June 2009, Florida

• Transmitted multidrug-resistant HIV persists in PBMC DNA for years

• Low-level Q148R in people without integrase inhibitor experience

• Cut-offs suggested for predicting efavirenz failure with low-level K103N

• Lower M184V rates with FTC/TDF than with 3TC/TDF

• HBV resistance to lamivudine at undetectable and low levels of viremia

Antiretrovirals

• Raltegravir approved in the US for treatment-naive patients: paranoia and anxiety added as side effects

Guidelines

• UK (BHIVA) guidelines online for comment (2009)

TB coinfection

• TMC207 reduces time to sputum conversion in phase II trial on patients with drug-resistant TB

Basic science and immunology

• Maximum suppression: ART intensification does not reduce residual viral load

• The role of Ad5-specific CD4 T-cells in enhancing risk of HIV acquisition in the Merck vaccine trial

• Tracing HIV reservoirs

• Illuminating early events in HIV infection using single genome amplification