April 2025

Contents

Journal scan

• Viral failure on CAB/RPV-LA: overcoming drug resistance with second-generation INSTIs

• Lancet Commission on gender justice and equality

• Lancet HIV recognises Transgender Day of Visibility and the importance of gender-affirming hormones in HIV care

• People living with HIV need two shots of the mpox vaccine and likely a booster after two years

Conference reports

• The RIO study: Q&A about controlling HIV with bNAbs

• CROI 2025: Webcasts and other resources now open access

• Continued reports from CROI 2025

• CROI 2025: LAPTOP, EC rebounds after 32 years, two more HSCT cures

• CROI 2025: Rebecca Denison gives opening community talk on 40 years of HIV

• CROI 2025: BHIVA best of CROI feedback now online

• CROI 2025: Two bNAbs enable viral suppression off-ART in African women in the FRESH cohort

Antiretrovirals

• Lenacapavir EAP in the UK closed to new referrals: NHS England and Gilead fail to agree a price after more than two years

Treatment access

• Changes to US policy jeopardises the lives of 500,000 children living with HIV by 2030