How long Biktarvy stays in the body after missed doses?
I’ve been skipping my meds, how long do they stay in my body for? I’m using Biktarvy.
The easy answer is that all three drugs in Biktarvy get very good drugs levels. They all leave the body slowly enough to cover any one missed dose, and possibly two (it is however better to still take this medication daily).
This is especially true after someone has been taking Biktarvy every day for several weeks. This is because the drug levels get steadily higher each day until they reach something called “steady state”.
The time it takes for drugs to leave the body varies for each drug and each body compartment, but is linked to the half-life. This is the time it takes for a drug level to drop by 50% from the early highest peak level. It then takes 5 x half-life for a drug to be effectively eliminated from the body.
The half life of every drug should be included in the detailed product leaflet (SPC) – links to these are included for each drug here:
Bictegravir has a plasma half-life period of 17.3 hours allowing for once daily dosing in combination with FTC and TAF which have intracellular half-lives of 39 and 150 hours respectively.