Q and A


Are there interactions between Ranega (TLD) and over the counter meds?


Hi there

Ranega is a very good HIV medicine. It contains three generic meds in single pill.

The three meds are tenofovir DF, lamivudine and dolutegravir – often called TLD.

There are very few interactions between these drugs and over-the-counter meds.

However, dolutegravir can interact with some supplements (containing calcium, magnesium or aluminium), antacids and multivitamins. This requires separating the dolutegravir dose by at least four hours. Another important interaction is that dolutegravir doubles levels of metformin, and requires careful monitoring.

Tenofovir can sometimes interact with other meds processed by the kidneys. This includes some non-steroidal anti-inflammatory drugs (NSAIDs) that are sold over the counter. For example: diclofenac, ibuprofen and naproxen. Please talk to your doctor or pharmacist if you often need to use these drugs.

This combination is produced by lots of different manufacturers which all contain the same meds.

For example the following meds used in South Africa all include the same three meds: Acriptega, Dovimil, Emdolten, Lanograv, Lavern, Luvigen, Milutin, Nuvaco, Odystra, Reydin, Telado, Telatri, Temiv, Tladeez, Viripil and Volutrip.

This link has more information about generic meds:


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