Question

Can I extend 2-1-1 PrEP dosing?

17 February 2024. Related: All topics, PrEP.

Hello,

I have a couple questions regarding on demand prep.
It says to take 2-1-1 but also to keep taking prep for 2 days after last sex encounter. What if the day of having sex is the same day I’m taking the second dose (1 pill). So my last dose (1 pill) would be closer to 24 hours after sex not 48 if one were to follow the 2-1-1. Should I take another pill so as longs as it’s 48 hrs? Which would probably be more like taking 2-1-1-1 (total of 5 pills not 4).
Second question. If I’m restarting on demand with one pill because it’s been less than 7 days since last on demand regimen, is it also required to take it at least 2 hours before having sex again or does it matter since it’s considered you have Truvada protection still in your body?

I’d appreciate any clarification .

Thanks in advance .

Answer

Answer: Josh Peasegood

Hi, how are you doing?

As you have mentioned you should take another pill. 2-1-1-1 dosing is suitable.

In this event it works similar to daily dosing. The initial dose is a ‘loading’ dose and is the main reason to being different to daily dosing.

It is okay to continue with as many doses as you need to ensure you have 2 days of PrEP after the last time having sex.

For your second question, you do not need to take PrEP at least 2 hours before. You will already have a level of PrEP in your body. This time requirement is only needed for the initial double dose if having sex on that day.

Josh.