Question

Are there interactions between my HIV meds and valproic acid (Depakote)?

29 May 2025. Related: All topics, Drug interactions.

I am taking tenofovir disoproxil fumarate, lamivudine, and dolutegravir combination, but I am also taking Depakote for bipolar. My doctor assured me that it is ok. Is it ok? Should there be intervals between taking these two medicines?

Answer

Answer: Simon Collins

Thanks for your Q and it is good to check about drug interactions.

It is good that your doctor checked – and they are giving you good advice and treatment.

Depakote does have a lot of potential interactions, including with some HIV meds. However, there are no interactions though with the HIV meds in your combination.

You can also take your meds at the same time as your HIV meds can be taken with or without food.

I hope you are doing well