Q and A

Question

Are HIV positive people at higher risk for coronavirus and COVID-19?

Hi, with all the news about coronavirus, am I at higher risk because I am living with HIV? I am on treatment with an undetectable viral load and a good CD4 count.

Answer

Hi

Thanks for your question. This Q&A answer was updated on 7 and 2 April and on 25, 23, 21, 20, 19, 18, 17, 14 and 10 March from a question first posted on 27 February. Recently updated text is in bold. It will be continue to be updated. Please bookmark and check again later).

The news about COVID-19 (coronavirus disease 2019 – the disease linked to this strain of coronavirus) is changing each day. But (so far) there is very little data about how it affects people living with HIV. Although there is no data to suggest that HIV positive people are at any higher risk, HIV is sometimes included in the list of health conditions you need to be extra careful about. This will depend on your CD4 count and other factors. 

  1. People with CD4 above 200 and undetectable on ART: follow general population advice (ie social physical distancing).
  2. People with CD4 that is 50 to 200, who have detectable viral load or who are not on ART: follow social distancing advice very closely.
  3. People with a CD4 count <50 or opportunistic illness in last 6 months: follow shielding advice for extremely vulnerable. This includes avoiding face-to-face contact for 12 weeks – and you will need support to do this.

This statement updates government advice for the general population to stay home.

  • People should only go outside for food, health reasons or work (where this absolutely cannot be done from home).
  • To stay 2 metres (6 feet) away from other people;
  • Wash your hands as soon as you get home.

This answer is based on the following public statements.

  • Information from Public Health England on 16 March 2020 included anybody who is HIV as an increased risk. This has since been updated to depend on CD4 count and use of ART (see below).
  • WHO advice, published on 17 March 2020 stated that the risks for people on effective HIV treatment (ART) who have a good CD4 count are similar to risks for the general population.
  • The BHIVA statement on 19 March 2020 stated that being on effective ART makes risks similar to general population, but that having a low CD4 count (less than 200 cells/mm3) might increase risk.
  • A joint EACS/BHIVA statement on 20 March 2020 also emphasised that neither ART nor PrEP can prevent or treat COVID-19.
  • US HHS guidelines published on 20 March 2020 are similar to the BHIVA and WHO interpretation, with a caution for having a CD4 count <200 cells/mm3.
  • On 23 March 2020, a new BHIVA statement explained that having a CD4 count <50 cells/mm3 mean following UK government advice for social shielding” for people who are extremely vulnerable. This means minimal face-to-face contact for 12 weeks. Not being on ART, having a CD4 count between 50 and 200, or having a detectable viral load makes it more urgent to closely follow social physical distancing.
  • On 25 March, BHIVA added statements on government advice for people who are extremely vulnerable and about managing HIV positive women who are pregnant.
  • On 31 March 2020, a BHIVA statement stressed that being on effective ART meant HIV positive people have a similar life expectancy to beingHIV negative. This was essential so that if limited resources limits access to care for people with coronavirus, HIV positive people are not excluded.
  • On 1 April 2020, EACS and BHIVA issued another joint statement. This emphasised that many HIV positive people often have similar additional risks to the general population. For example, older age of other health problems. It also detailed new research projects to collect information about HIV positive people who catch coronavirus.
  • Although limited evidence, HIV positive people in Wuhan city in China didn’t appear to have been more affected by COVID-19 than the general population.

There is also limited data about COVID-19 and other populations with lower immunity. So the general advice is to follow the news for any announcements by your national health authority. This information is rapidly changing.

COVID-19 is currently major news and this is likely to continue for some time. As seasonal influenza routinely affects many more people, including having serious and fatal outcomes, getting the pneumococcal and seasonal flu vaccines (see below) was originally important. However, with the latest information about restricted social interactions and priority access to GP and other services, this might now be more difficult. For the UK and other countries moving into spring an summer, the flu vaccine is not so important as the flu season is ending.

Older people (because immune function reduces after age 60) are at higher risk from COVID-19. This is especially if older than 70 and even more so if older than 80. This is based on observations in the general population in China, Italy and other high incidence settings. However, serious cases have included younger people dying from COVID-19, including two cases in the UK, (aged 13 and 19).

Other chronic health conditions also increase the risks with COVID-19. For example, having heart disease, kidney disease, diabetes, lung/breathing problems and cancer. Smoking is also a risk. HIV is included in this list by the UK government. BHIVA (UK), European, WHO and US guidelines see HIV positive people on ART as being at similar risk to general population.

Some other people who have lowered immunity, such as pregnant women and young children, have not so far been at higher risk from COVID-19. This might just be because they came into less contact with risk. At least one case has reported transmission of COVID-19 either during pregnancy or at birth. Other cases did not see this. US guidelines link to detailed information about pregnancy and also about children.

If COVID-19 is likely to be a higher risk for HIV positive people, this might be related to having a low CD4 count. This opinion is not supported by evidence from the general population. Anyone on treatment with a CD4 count above 500 is considered similar to being HIV negative. Even having a CD4 count between 350 to 500 is still very good, especially if viral load is undetectable on treatment. However, there is no data so far to support the view that a lower CD4 count has any effect on COVID-19.

Having a CD4 count under 200, not being on ART or not having undetectable viral load might increase any risk. This makes it more important to follow general advice more strictly. This includes good practice like washing your hands and minimising touching your face. It also makes “social physical distancing” more important. This is not the same as self-isolation or social distancing. It is important for your well-being to keep in contact with friends and family by phone, video calls and social media.

During flu season HIV positive people are recommended to get vaccinated each year. It is also recommended to have the pneumococcal vaccination (PCV-13) (at any time of the year if you haven’t had this) which provides cover for 5-10 years (see below for details).

From the outset, older HIV positive people and those with other health conditions, need to be especially careful. This should not be interpreted that being young will protect you. As the epidemic spreads, serious cases in much younger people have been reported.

  • Transmission is largely from microdroplets in air breathed out from someone during the infectious period (generally <1 day before symptoms to average 5 days, but up to 14 days).
  • As well as the direct risk from breathing in these droplets if someone has just sneezed or coughed without shielding themselves, these can remain infectious on hard surfaces for an unknown time. This is likely to be at least several hours which is why hand-washing and not touching your face is important.
  • Best ways to minimise risk of infection include washing your hands more carefully – for at least 20 seconds – and frequently – and not touching your face.
  • Soap and water is better than hand sanitisers (and more readily available).

Trials of remdesivir – the best current treatment – are already underway, including in the UK, and a candidate vaccine is expected to be fast-tracked. Of interest, some HIV medicines (including lopinavir/r) are being looked at to treat COVID-19, though evidence supporting any benefit is also very limited.

An overview of COVID-19 was included in the recent CROI 2020 conference. (View webcast from CROI 2020).

The UK government also provided more information about what is involved in “self-distancing” for people at higher risk. This is different to “self-isolation”. Please read here for information about self-distancing.

Does PrEP or HIV meds (ART) protect against or treat coronavirus?

No. Neither HIV meds nor PrEP reduce the risk of catching coronavirus. They also will not help to treat coronavirus. 

British HIV Association (BHIVA) statements on coronavirus and HIV

BHIVA have posted ten online statements about COVID-19. They are collected on this page where future updates will be added.

2 comments

  1. Roy Trevelion

    Hi Lobi,

    The good news is that it doesn’t mean that.

    If you are undetectable and with a CD4 count above 200 the risk of COVID-19 is the same as the general population. But it’s important that everyone follows the social physical distancing advice. If you have a lower CD4 count, especially if it’s less than 50 and you have another infection you should follow shielding advice.

    Treatment for TB is with antibiotics, and these will continue to work against TB.

    Please let us know what HIV meds you’re taking. And if you have access to your CD4 count and viral load results, please let us have these too.

  2. Lobi

    Does all this mean that , even if u are lower than detectable you are at risk, your immune is not strong enough, but then you find most of the LDL are hardly sick of flue or cold for years ,

    WHAT ABOUT THE TB (TUBERCULOSIS) treatment does that mean it won’t work?

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