Glossary

active – an active drug is a drug that still works to reduce viral load. The virus is still sensitive to that drug.

performance stage – WHO classification of progress of HIV infection.

WHO classification system.

non-nuke – a common term for NNRTI.

TB (tuberculosis) – a bacterial infection that commonly affects the lungs (pulmonary TB) but which can also affect most other organs.

TB section of the training manual.

revertant mutation – this term is used in two ways.

Firstly when referring to a genetic change that shows the virus is returning from a drug resistant mutation back to a wild-type genotype. This can sometimes take several stages. For example, T215E/D/E and S are revertant mutations that can indicate the drug resistant mutation T215Y is being replaced by wild-type (i.e. T215T).

It can also refer to the fitness of a virus. A revertant mutation can refer to an additional mutation that allows the virus to regain viral fitness (most drug mutations also make the vurs less fit). The second example is called a compensatory mutation as is compensates for the reduced fitness caused by the first mutation.