Glossary

lactate – waste product produced when sugar is turned into energy by the body.

minor mutation – a drug resistance mutation that have a big impact on whether a drug continues to work. This used to be called a secondary mutation.

integrase inhibitor – a type of HIV drug that stops HIV genetic material from ‘integrating’ into the DNA in a cell.

This is a relatively new family of HIV drugs.

Raltegravir, elvitegravir and dolutegravir are all integrase inhibitors.

reverse transcriptase – an enzyme unique to HIV. It is used to convert single-strand RNA into double-strand DNA. This is needed before HIV’s genetic material can be integrated in the human DNA. HIV drugs that stop this process are called reverse transcriptase inhibitors (RTIs).

late breaker – in research, this is a study presented at a medical meeting that was submitted to the conference organisers after the main programme had been decided. There are usually only a few dozen late-breakers, where the last minute results are thought important enough to include – like ‘late-breaking news’. Although this studies often contain the most exciting news, they are given much less time to present their results – maybe less than 10 minutes compared to a normal 15 or 20 minute session. These summary results are also difficult to verify because they include fewer slides and fewer details.