expanded access programme (EAP) – a scheme that allows people to access a drug before it has been approved (but when approval is expected).
EAPs are for people urgently need treatment as a life-saving option and who do o have the time to wait for the six months that it takes for approval to be finalised. EAPs are usually available for most HIV drugs after the main studies (phase 3) have been completed.
They were an important early result of community activism. They are also called ‘early access’ or ‘named-patient’ programmes.
base – (also called nucleotide) – the building blocks in DNA that form amino acids. There are four bases represented by the letters A (adenine), T (thymine), C (cytosine) and G (guanine). In RNA the T is replaced by U (uricil).
Genetics, HIV structure and life cycle
HIV transmission is when the virus passes from one person to another. When this is from mother to baby it is called mother-to-child transmission (MTCT), perinatal or vertical transmission. Children who become HIV-positive in this way are called vertically infected children
undetectable – an amount smaller than a test can measure. For viral load tests, this means below 400 or, more commonly, below 50 copies/mL, depending on the make of test. In research laboratories, some very sensitive tests can measure down to 1 copy/mL.
Immune reconstitution inflammatory syndrome – see: IRIS
