Glossary

in vitro – a study in a test tube. Literally, ‘in glass’.

PT (prothrombin time; pro-time) – PT testing measures the amount of time it takes for blood to clot. When the liver is damaged, its ability to make clotting factors is impaired. If this time increases – referred to as a prolonged PT interval – it shows that the liver is not working so well.

IV (intravenous) – injecting into a vein. See SC (sub-cutaneous) and IM (intra-muscular).

NRTI – Nucleoside Reverse Transcriptase Inhibitor, a type of HIV drug – also called ‘nuke’ or ‘nucleoside analogue’.

3TC (lamivudine). abacavir, AZT, FTC (emtricitabine), d4T (stavudine), ddI (didanosine) all belong to this class.

Tenofovir DF and tenofovir alafenamide (TAF) are a nucleotide analogues which is similar enough to be counted as part of this class.

Drug targets in the virus life cycle.

nanotechnology – science working with tiny particles at the level of manipulating individual molecules. This is an exciting field of medicine. Drugs developed with nanotechnology would need much lower drug doses (hopefully cheaper and having fewer side effects) and would be longer lasting (perhaps being taken every2–4 weeks).