Glossary

benign – not harmful.

nanotechnology – science working with tiny particles at the level of manipulating individual molecules. This is an exciting field of medicine. Drugs developed with nanotechnology would need much lower drug doses (hopefully cheaper and having fewer side effects) and would be longer lasting (perhaps being taken every2–4 weeks).

fusion inhibitor – a type of HIV drug (an entry inhibitor). Fusion inhibitors stops HIV ‘fusing’ to a CD4 cell. T-20 (enfuvirtide, Fuzeon) is only currently licensed fusion inhibitor.

Drug targets in the virus life cycle.

non-nuke – a common term for NNRTI.

tropism – the type of coreceptor used by HIV in order to attach to and then infect a cell. If HIV uses the CCR5 coreceptor on the surface of the a CD4 cell it is called R5-tropic. If it uses the CXCR4 co receptor it is called R4-tropic). Early HIV infection is usually R5-tropic but over time, especially in late disease (if CD4 counts drop to less than 50 cells/mm3) the virus shifts to being X4-tropic.  Mixed tropic refers to a having some viruses that use R5 and some that use X4.