preclinical refers to the early development stage for a new drug, before any testing on humans. This includes they laboratory and animal tests. Preclinical studies will not always show what will happen when people use the drugs, but can provide a guide to serious problems that could occur.
Glossary
Selected words and phrases
drug resistant mutation – a mutation or change that occurs in the HIV genome that reduces a drugs ability to work.
lesion – damage to a part of the body.
HCV – hepatitis C, a virus that causes liver disease.
base – (also called nucleotide) – the building blocks in DNA that form amino acids. There are four bases represented by the letters A (adenine), T (thymine), C (cytosine) and G (guanine). In RNA the T is replaced by U (uricil).