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Glossary

Selected words and phrases

SVR (sustained virological response) – having a negative HCV viral load test 6 months after stopping HCV treatment. The response, 6 months after treatment is stopped, determines whether treatment has been effective in terms of clearing HCV. SVR is the most important result from an HCV treatment trial. See ETR.

selective pressure – this is when a factor in the environment causes one type of organism to develop and grow in preference to another. With HIV drug resistance, the presence of a drug exerts selective pressure for resistance to develop. It is based on evolution and the concept of ‘survival of the fittest’ theory developed by Charles Darwin.

PCP – pneumocystis jiroveci (new) or pneumocystis carinii (old). A fungal infection that causes pneumonia.

PCP section of the training manual.

fold-change – a term relating to drug resistance after a phenotype resistance test.

4-fold resistance (also called a 4-fold loss in sensitivity) means you need to use four times the dose to get the same reduction in viral load.

chorionic villus sampling – test in which cells around an embryo are removed and examined to detect genetic abnormalities.