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Glossary

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fibrotest – a test which uses results from blood tests to predict liver damage and which may become an alternative option to liver biopsy in some patients.

Summary of Product Characteristics (SPCs) – detailed information about a drug provided by the maker that is approved by the European Regulatory Agency (EMEA/CPMP). Also called EPARs.

EMEA published SPCs

HPV (human papillomavirus) – a family of viruses associated with cervical cancer and anal cancer and genital warts.

Cardiovascular refers to the heart and blood vessels.

Cardiovascular disease (CVD) is the general term for disease to the heart and related blood vessels.

On-demand dosing – a term for taking medicines only at times linked to a relevant event.

On-demand dosing for PrEP is also called “event-based dosing” (EBD).

For example, on-demand dosing for PrEP (to prevent HIV transmission) involves taking PrEP before sex and then for several days after sex.

For many years, on-demand dosing referred to 2:1:1 dosing. This was an option for cisgender gay and bisexual men using PrEP. This involves starting with a double dose (two pills), taken 24 to 2 hours before sex, and then single daily doses for the two days after sex.

In 2025, UK (BASHH) and European (EACS) PrEP guidelines included 2:7 on-demand dosing for cisgender women and for transgender and non-binary people.