Glossary

publication bias – the tendency for published results to be different to other trials. For example, trials that show a positive effect are more likely to be reported and published than trials that find no effect.

capsid inhibitor – this is a new type of HIV drug that works at several different stages of the HIV lifecycle.

Lenacapavir is currently to only approved capsid inhibitor. The long-acting HIV med only needs to be given by subcutaneous injection every six months.

weight loss – a general reduction in weight. Weight loss can often be a symptom of other opportunistic infections.

Weight loss and wasting section of the training manual.

gastrointestinal tract (or GI tract) is where we digest our food. It is a long tube that runs from the mouth to the anus. The gastrointestinal tract begins with the mouth and then becomes the oesophagus (food pipe), stomach, duodenum, small intestine, large intestine (colon), rectum and, finally, the anus. It is also called the GI tract.

baseline – baseline refers to the start of any period being studied. For someone who is HIV positive, their baseline CD4 and viral load counts are the first tests they ever had taken. For someone entering a study, the baseline results refer to their test results at the start of the study. Baseline results for following resistance refers to the results of the first resistance test.