surrogate marker – A surrogate marker is when something that is easy to measure is used as a marker for something that is difficult to measure directly.
The CD4 count doesn’t directly measure HIV. But it is a good surrogate (or indirect) marker for how HIV has damaged your immune system. It is closely linked to the risk of HIV-related complications.
Viral load in blood is a good surrogate marker for levels of HIV in your body overall including in other body sites.
fulminant liver disease – sudden, rapid disease progression related to liver failure.
replicate – to duplicate, copy or reproduce. It is more scientifically accurate to refer to a virus replicating than reproducing.
microbicide – a gel that may protect against infection.In reference to HIV, this is usually referring to a gel that could be applied before sex. In 2010 a study called Caprisa 004 provided the first evidence that a microbicide (in this case a gel containing the HIV drug tenofovir) might protect against HIV infection.
outreach – a type of service which goes out to find and engage people.