Glossary

baseline – baseline refers to the start of any period being studied. For someone who is HIV positive, their baseline CD4 and viral load counts are the first tests they ever had taken. For someone entering a study, the baseline results refer to their test results at the start of the study. Baseline results for following resistance refers to the results of the first resistance test.

preclinical refers to the early development stage for a new drug, before any testing on humans. This includes they laboratory and animal tests. Preclinical studies will not always show what will happen when people use the drugs, but can provide a guide to serious problems that could occur.

severity – a measure of how bad something is.

inhibition (in the liver) – refers to the body processing a drug more slowly by inhibiting (or reducing) the enzymes that clear the drug. This leads to higher drug levels.

Area Under the Curve (AUC) – total exposure to drug over the dosing period.