Glossary

fulminant liver disease – sudden, rapid disease progression related to liver failure.

half-life (T1/2) – the time taken a drug to clear from the highest concentration to half this level. Drugs have different half-lives in different compartments (ie half-life in blood can be different from the half-life inside a cell). It take 5 x the half-live for a drug to be considered cleared.

percutaneous – umbilical cord sampling see cordocentis.

NNRTI – Non-Nucleoside Reverse Transcriptase Inhibitor, a type of HIV drug – also called ‘non-nuke’.

Efavirenz, nevirapine, rilpivirine, etravirine and doravirine are all NNRTIs.

Drug targets in the virus life cycle.

Listing of NNRTIs.

DEXA – a non-invasive scan that can measure the percentage of different body areas (whole body, trunk, right leg etc) that are muscle or fat. DEXA scans cannot determine if this is central fat (visceral adipose tissue, VAT) or sub-cutaneous fat (under the skin).

DEXA scan also can measure bone density and is used to monitor risk of osteopenia and osteoporosis.