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2025 edition and access to HIV PrEP in the UK

This 2025 edition is very similar to the 2024 version.

The main change is that the new UK guidelines for HIV PrEP are now published. 

  • Everyone who can benefit from HIV PrEP should now be able to get it. You no longer have to be at high risk. 
  • Everyone now has the option to quick-start PrEP using a double first dose (two pills), working within two hours.
  • Adherence to daily dosing doesn’t have to be so strict. Everyone taking four or more doses each week will still have very high levels of protection.
  • Event-based dosing can also now be used by everyone. This uses either 2:1:1 or 2:7 dosing.
  • New info covers starting and stopping PrEP and new versions of PrEP (TAF/FTC and injectables).
  • These changes are based on a review of over 150 new studies.
  • We include new links to information about HIV PEP and doxyPEP.

Getting PrEP in the UK

PrEP is now available free from sexual health clinics across the UK. It can also still be bought online.

These sites have more information, including on how to find a sexual health clinic by postcode.

If a doctor does not want to prescribe you PrEP, please ask them why. If this is for a medical reason, they should explain this. Or they might not know about the new UK guidelines.

If you still cannot access PrEP, ask to speak to a more senior doctor. If there is still a problem please email i-Base.

See also: information about buying PrEP online from the UK.

PrEP and mpox (monkeypox)

Luckily, mpox is now only rarely reported in the UK. However, vaccination is still available and important.

PrEP will not protect against mpox.

Mpox vaccination is still recommended.

PrEP and COVID-19

Many PrEP clinics rearranged services because of COVID-19.

This might involve testing less frequently for HIV and STIs, and maybe longer prescriptions.

PrEP is still just as safe and effective.

Last updated: 1 August 2025.