7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon
11 June 2006. Related: Conference reports, Conference index, PK Workshop 7th 2006.
The following articles are included in our coverage of this years PK meeting held this year in Lisbon from 20-22 April.
- Efavirenz levels above recommended upper target in 20% of African patients in Senegal
- Lower dose of AZT provides adequate exposure in patients with low body weight
- Pharmacokinetics for generic fixed dose combinations for children are comparable to the branded products
- Caution against dividing adult FDCs (Triomune) for young children
- University of Liverpool audit of paediatric TDM
- Age-dependent pharmacokinetics of 3TC in children
- Use of small sample drug level monitoring for paediatric PI concentrations
- Intracellular and plasma measurements of AZT and 3TC and their metabolites in neonates
- Effect of pregnancy on PK of protease inhibitors
- Using enzyme inducers to reduce the half-life of nevirapine
- Relationship between nevirapine concentrations and virological failure in a clinical setting
- Summary of drug interaction studies
- Effects of ketoconazole and rifampin on TMC278
- Brecanavir interaction study with ritonavir and atazanavir
- Fixed-dose formulation of efavirenz/tenofovir/FTC bioequivalent to separate dosing
- Saquinavir/r (1000/100mg) levels reduced when taken fasted and should be taken with food
- Lack of food effect with Meltrex formulation of lopinavir/r
- Food interaction reduces ddI intracellular absorption and supports requirement to take fasted
- Conflicting results on how T-20 affects tipranavir
Unless stated otherwise, references are to the Programme and Abstracts of the 7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon.
Abstracts and presentations from the meeting are already available online at: