PK Workshop 7th 2006

7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon

Efavirenz levels above recommended upper target in 20% of African patients in Senegal

Lower dose of AZT provides adequate exposure in patients with low body weight

Pharmacokinetics for generic fixed dose combinations for children are comparable to the branded products

Caution against dividing adult FDCs (Triomune) for young children

University of Liverpool audit of paediatric TDM

Age-dependent pharmacokinetics of 3TC in children

Use of small sample drug level monitoring for paediatric PI concentrations

Intracellular and plasma measurements of AZT and 3TC and their metabolites in neonates

Effect of pregnancy on PK of protease inhibitors

Using enzyme inducers to reduce the half-life of nevirapine

Relationship between nevirapine concentrations and virological failure in a clinical setting

Summary of drug interaction studies

Effects of ketoconazole and rifampin on TMC278

Brecanavir interaction study with ritonavir and atazanavir

Fixed-dose formulation of efavirenz/tenofovir/FTC bioequivalent to separate dosing

Saquinavir/r (1000/100mg) levels reduced when taken fasted and should be taken with food

Lack of food effect with Meltrex formulation of lopinavir/r

Food interaction reduces ddI intracellular absorption and supports requirement to take fasted

Conflicting results on how T-20 affects tipranavir