June 2006

Contents

Editorial

• Volume 7 Number 6 June 2006

Conference reports

• 7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon

• Efavirenz levels above recommended upper target in 20% of African patients in Senegal

• Lower dose of AZT provides adequate exposure in patients with low body weight

• Pharmacokinetics for generic fixed dose combinations for children are comparable to the branded products

• Caution against dividing adult FDCs (Triomune) for young children

• University of Liverpool audit of paediatric TDM

• Age-dependent pharmacokinetics of 3TC in children

• Use of small sample drug level monitoring for paediatric PI concentrations

• Intracellular and plasma measurements of AZT and 3TC and their metabolites in neonates

• Effect of pregnancy on PK of protease inhibitors

• Using enzyme inducers to reduce the half-life of nevirapine

• Relationship between nevirapine concentrations and virological failure in a clinical setting

• Summary of drug interaction studies

• Effects of ketoconazole and rifampin on TMC278

• Brecanavir interaction study with ritonavir and atazanavir

• Fixed-dose formulation of efavirenz/tenofovir/FTC bioequivalent to separate dosing

• Saquinavir/r (1000/100mg) levels reduced when taken fasted and should be taken with food

• Lack of food effect with Meltrex formulation of lopinavir/r

• Food interaction reduces ddI intracellular absorption and supports requirement to take fasted

• Conflicting results on how T-20 affects tipranavir

Treatment strategies

• Autologous stem cells transplant (ASCT) in HIV-positive individuals with a relapsed non-Hodgkin’s lymphoma (NHL) or Hodgkin’s disease (HD)

Treatment access

• ITPC publish updated report on access to treatment

• Protesters evicted from UN headquarters, New York

• Community opposition filed against tenofovir patent application in India

Guidelines

• US adult treatment guidelines updated (May 2006)

• Draft BHIVA immunisation guidelines online (2006)

TB coinfection

• HIV linked to lower rifampin and ethambutol AUCs in TB cohort

Drug resistance

• Web resources for HIV-1 genotypic-resistance test interpretation

Other news

• LGV in the UK: almost 350 cases reported and still predominantly affecting HIV-positive gay men

On the web

• Conference abstracts and reports

• HIV InSite: new chapters

• PLoS Medicine articles

• New HIV vaccine website

PDFs

• Volume 7 Number 6 June 2006 PDF