WHO update PrEP guidelines to include event-based dosing

30 September 2019. Related: Guidelines, HIV prevention and transmission.

Simon Collins, HIV i-Base

On 13 July 2019, WHO published a technical brief to update the current WHO recommendation on oral PrEP to include an option of event-driven dosing for men who have sex with men.

This technical brief aims to:

• Update the dosing considerations for oral pre-exposure prophylaxis (PrEP) containing TDF for men who have sex with men.
• Summarise current evidence on the safety and efficacy of event-driven PrEP (ED-PrEP). 
• Describe the rationale for offering ED-PrEP as an alternative to daily oral PrEP to men who have sex with men as part of comprehensive HIV prevention and sexual health services.
• Discuss considerations for offering ED PrEP to men who have sex with men, including clear messaging on how men who have sex with men can switch from ED-PrEP to daily dosing (and vice-versa).

Reference:

WHO. What’s the 2+1+1? Event-driven oral pre-exposure prophylaxis to prevent HIV for men who have sex with men: Update to WHO’s recommendation on oral PrEP. July 2019.
https://www.who.int/hiv/pub/prep/211/en