Continued evidence for poorer COVID-19 outcomes in people with HIV  

Simon Collins, HIV i-Base

Several studies in Lancet HIV have added to evidence supporting an independent association between HIV and worse outcomes from COVID-19.  [1, 2 ]

Editorial commentary in the same issue by Marta Boffito and Laura Waters nicely summarise both studies and discusses potential explanations for these results. [3]

About a month ago, HTB reported the US study by Yang et al when still a pre-press article. It is perhaps the most thorough and convincing dataset of people living with HIV so far. [4]


  1. Nomah DK et al. Sociodemographic, clinical, and immunological factors associated with SARS-CoV-2 diagnosis and severe COVID-19 outcomes in people living with HIV: a retrospective cohort study. Lancet HIV. 2021. DOI: 10.1016/S2352-3018(21)00240-X. (13 October 2021).
  2. Yang X et al. Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data. Lancet HIV. 2021. DOI: 10.1016/S2352-3018(21)00239-3. (13 October 2021).
  3. Boffito M and Waters L. More evidence for worse COVID-19 outcomes in people with HIV. Lancet HIV. DOI: 10.1016/S2352-3018(21)00272-1. (13 October 2021).  
  4. HIV increases risk of severe COVID-19 in largest US study. HTB (17 September 2021).

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