October 2000

Contents

Conference reports

• 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy, Toronto, Canada, 13-15 September 2000

• Lipodystrophy: the current state of play

• Metabolic effects – bone density and avascular necrosis

• Lipoatrophy and facial wasting

• Lactic acidosis

• Lipodystrophy and metabolic changes in children

• 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, 17-20 September 2000

• Mitochondrial toxicity reports

• Treatment interruption and salvage therapy

• Are gender-related differences in viral load present in infants and children?

• Immune reconstitution in children treated with HAART is independent of age

• Pharmacokinetics in children and infants

• Opportunistic illness and viral hepatitis co-infection

Antiretrovirals

• United States FDA approves Kaletra for HIV infection

Treatment strategies

• Study shows immune system can control HIV: early antiviral treatment primes the immune system to suppress viral levels without drugs

• Human IL-12 may augment HIV-specific immunity in HIV-positive patients

Side effects

• Crystalluria common in HIV-positive patients using indinavir

Coinfections and complications

• Highly active antiretroviral therapy should continue even if immune restoration syndrome develops

Basic science and immunology

• Enhancement of HIV type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption

Vaccines and microbicides

• United Kingdom authorities clear AIDS vaccine for human testing

PDFs

• Volume 1 Number 7 October 2000 PDF