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2001
December
HTB
December 2001
Contents
Conference reports
3rd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Athens, 23-26 October 2001
Insulin resistance
Thyroid function abnormalities
Lipodystrophy and metabolic changes in children
Bone studies at lipodystrophy workshop
Antiretrovirals
Delaying antiretroviral therapy may be considered for many patients
Correlation between reduction in plasma HIV1 RNA concentration 1 week after start of antiretroviral treatment and longerterm efficacy
One week on, one week off experimental regimen might reduce the cost and toxicities of HIV therapy
Enteric coated didanosine significantly reduces nausea, bloating, GI upset
Secondary mutations in HIV-1 protease predict treatment failure in naive patients
Antiretroviral regimen complexity, self-reported adherence, and HIV patients’ understanding of their regimens: survey of women in the HERS study
Study indicates NNRTI mutations have little effect upon HIV-1 replicative capacity
Treatment access
Survey reveals pregnant Zambians support universal nevirapine treatment
Paediatric care
Syncytium inducing viral phenotype halves thymic T cell production in children
Children with advanced disease who take HAART experience immune reconstitution
PK and drug interactions
Garlic can impede HIV medication
Caution needed with nelfinavir and some lipid-lowering drugs
Guidelines
New US guidelines for the prevention of opportunistic infections in people infected with HIV
Side effects
Elevated blood pressure in subjects with lipodystrophy
Fat distribution is strongly tied to metabolic disturbances in HIV lipodystrophy
Eating more often can reduce cholesterol levels
Coinfections and complications
Incidence and prognosis of AIDS-related lymphoma have improved since the advent of HAART
TB coinfection
Coinfection does not appear to augment TB infectivity
Basic science and immunology
Detailed picture emerges of how HIV travels into and out of cells
High levels of HIV replication shut down anti-HIV immune responses
Natural killer cell activity varies with viral burden in HIV-1 infection
Other news
MDMA: acute effects of ecstasy on T-cell numbers and function
TRAIL ligand induces apoptosis of cells infected with HIV in-vitro
DHEA replacement therapy improves quality of life
Medicinal plant ‘fights’ AIDS
On the web
Review: treatment of chronic hepatitis
PDFs
Volume 2 Number 10 December 2001 PDF
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