4 May 2007

Contents

Conference reports

• No benefit of early cessation of breastfeeding in the Zambia Exclusive Breastfeeding Study (ZEBS)

• Role of infant feeding and HIV in a severe diarrhoea outbreak in Botswana

• Diarrhoea in uninfected infants of HIV-positive mothers who stop breastfeeding at 6 Months

• Post-weaning gastroenteritis and mortality in HIV-uninfected infants receiving antiretroviral prophylaxis

• Rates of diarrhoea associated with early weaning among infants in the Kisumu breastfeeding study

• Early breastfeeding cessation among infants and risk of serious gastroenteritis: findings from a perinatal prevention trial in Kampala, Uganda

• Treating children in resource-limited settings

• Pharmacokinetics of nevirapine, d4T, and 3TC in Zambian children treated with Pedimune (Triomune)

• New PK data for protease inhibitors

• Plasma concentrations of efavirenz and lopinavir in children with and without rifampicin-based TB treatment

• NNRTI vs PI HAART regimens for children in resource-limited settings

• Predictors of infant mortality

• HIV-infection in the brain, neurocognitive dysfunction and CNS drug penetration

• Selected genetics studies from CROI

• Report from genomics workshop at CROI

• 5th European HIV Drug Resistance Workshop, Cascais, Portugal, 29 March 2007

• Few integrase inhibitor (INI) mutations in INI-naive people

• Response to darunavir, tipranavir, or lopinavir after atazanavir failure

• Upper and lower clinical cutoffs proposed for darunavir

• Accuracy of Monogram’s Trofile assay in determining tropism and new tropism assays in development

• Several genotyping systems offer hope as tropism predictors

Treatment access

• Clinton Foundation announces significant price reductions for generic second-line drug and more tolerable first-line options

• Generic tenofovir licensed in South Africa

• Agreement for generic license of darunavir in South Africa

• Brazil issues plans to produce generic efavirenz

• Access to Abbott drugs in Thailand

• Indian government only plans to provide access to second-line ARVs after first-line drug treatment targets are met

• Increasing antiretroviral access for children

On the web

• HIV-positive women and drug and alcohol use

• WHO Bulletin: TB special issue