June 2021

Contents

Editorial

• HTB: no. 6 – plus HIV and COVID-19 (1 June 2021)

Conference reports

• 5th joint BHIVA/BASHH conference 2021

• Weight changes on ART and how to lose weight successfully

• Selected presentations at BHIVA: COVID-19, PrEP in the UK, community involvement and more…

• 28th Conference on Retroviruses and Opportunistic Infections (CROI 2021) virtual

• No differences in outcomes among women with and without HIV with high-risk pregnancies and COVID-19

• Dolutegravir-based regimens safe and effective in pregnancy and postpartum

• Dolutegravir superior to standard of care in children and adolescents: results from the ODYSSEY trial

Coinfections and complications

• High efficacy of HPV vaccine in HIV positive gay men

• HPV vaccine does not prevent short-term recurrence of high grade lesions in HIV positive gay men

HIV prevention and transmission

• HIV bNAbs prevent intravenous exposure to SHIV in macaques as PrEP

COVID-19: HIV and COVID-19 coinfection

• HIV associated with higher risk of severe COVID-19 in US cohort

• Reduced antibody responses to first dose of mRNA COVID-19 vaccines in HIV positive people with a lower CD4 count

• Novavax reports 43% efficacy against B.1.351 South African variant but negative impact in HIV positive participants

COVID-19: vaccine research

• MHRA authorises Janssen/J&J COVID-19 vaccination in the UK

• France routinely recommends third dose of COVID-19 vaccine for some people with reduced immune function

• US CDC reports 10,000 breakthrough infections after full vaccination: showing success of vaccine programme

• Cases of COVID-19 reported including deaths in care home residents after full-course vaccination

• Israeli study reports reduced vaccine efficacy in people with immune suppression until 14 days after the second dose

• Oxford/AZ vaccine linked to 242 rare bloods clots in the UK: alternative recommended for people younger than 40

• COVID-19 vaccine candidate from GSK and Sanofi to move to phase 3 placebo controlled study

COVID-19: treatment access

• Meta-analysis of 18 ivermectin studies

COVID-19: complications

• Missed TB diagnoses during COVID-19 outbreaks despite prolonged respiratory symptoms

COVID-19: pathogenesis

• Correlation between COVID-19 severity and immune responses after six months

• Durable antibody responses 9 months after exposure irrespective of symptoms: broader vaccine coverage still needed to reach herd immunity

COVID-19: transmission & prevention

• Asymptomatic infection has similar SARS-CoV-2 viral load to mild COVID-19

PDFs

• HTB: no. 6 – plus HIV and COVID-19 (1 June 2021)